منابع مشابه
The role of inflammation in ICU-acquired weakness
A pilot observational study by Weber-Carstens and colleagues contributes to a mechanistic explanation of the puzzling and complex phenomena of ICU-acquired weakness (ICU-AW). The authors suggest systemic, inflammatory-mediated pathology is the most significant risk factor for ICU-AW. While this finding is somewhat equivocal, it provides important direction for future investigations and illustra...
متن کاملICU-acquired weakness: should medical sovereignty belong to any specialist?
ICU-acquired weakness (ICUAW), including critical illness polyneuropathy, critical illness myopathy, and critical illness polyneuropathy and myopathy, is a frequent disabling disorder in ICU subjects. Research has predominantly been performed by intensivists, whose efforts have permitted the diagnosis of ICUAW early during an ICU stay and understanding of several of the pathophysiological and c...
متن کاملICU-acquired weakness and recovery from critical illness.
Copyright © 2014 Massachusetts Medical Society. W eakness acquired in the intensive care unit (ICU) is caused by many different pathophysiological mechanisms that are not mutually exclusive. This is not surprising, given the diverse diseases that precipitate critical illness, the drugs used during its management, and the consequences of protracted immobility. Nonetheless, conceptualization of t...
متن کاملImpact of ICU-acquired weakness on post-ICU physical functioning: a follow-up study
INTRODUCTION ICU-acquired weakness is thought to mediate physical impairments in survivors of critical illness, but few studies have investigated this thoroughly. The purpose was to investigate differences in post-ICU mortality and physical functioning between patients with and without ICU-acquired weakness at 6 months after ICU discharge. METHOD ICU patients, mechanically ventilated ≥ 2 days...
متن کاملMitochondrial function in skeletal muscle of patients with protracted critical illness and ICU-acquired weakness
BACKGROUND Mitochondrial damage occurs in the acute phase of critical illness, followed by activation of mitochondrial biogenesis in survivors. It has been hypothesized that bioenergetics failure of skeletal muscle may contribute to the development of ICU-acquired weakness. The aim of the present study was to determine whether mitochondrial dysfunction persists until protracted phase of critica...
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ژورنال
عنوان ژورنال: Intensive Care Medicine
سال: 2020
ISSN: 0342-4642,1432-1238
DOI: 10.1007/s00134-020-05944-4